https://scicomjournals.com/index.php/SJMAMS/issue/feed 2024-10-25T04:29:47-06:00 Managing Editor iapubseditor@gmail.com Open Journal Systems <p><strong>Journal Summary: </strong><strong>Scope:</strong> Publishes in all areas of Medical and Applied Medical Sciences. <strong>ISSN:</strong> Print and Online. <strong>Crossref DOI Prefix: </strong>10.54117. <strong>Frequency:</strong> Bimonthly (6 Issues per year). Jan, Mar, May, Jul, Sept, Nov. <strong>Journal model:</strong> Open Access. <strong>Article Processing Charges:</strong> Free. <strong>Abstracting &amp; Indexing:</strong> Google Scholar, Semantic Scholar, Index Copernicus, Crossref, WorldCat. <strong>Type of articles:</strong> All kinds of articles including book of abstracts and conference proceedings. <strong>Review type:</strong> Double-blind peer review. <strong>License type:</strong> CC BY 4.0. <strong>Area of coverage:</strong> biomedicine, anatomy, physiology, molecular medicine, genetics, medical laboratory science, and clinical science. Other areas include reproductive biomedicine, cell therapy, neuroscience, tissue engineering, biotechnology, cell line studies, pathology, biochemistry, microbiology, and pharmacology.</p> https://scicomjournals.com/index.php/SJMAMS/article/view/14 2024-02-29T13:58:53-07:00 Udo Orukwowu udocd27@gmail.com

<p>This study examined the knowledge, attitude and practice of modern family planning methods among men in Ogbogu Community in Ogba/Egbema/Ndoni Local Government Area of Rivers State. <strong>Introduction</strong>: &nbsp;Family planning is the practice that helps individuals or couples to attain certain objectives such as avoiding unwanted pregnancies, bringing about wanted babies at the right time, regulating the interval between pregnancies, controlling the time at which birth occurs in relation to the ages of the parents<strong>. Methodology</strong>: The study used a descriptive survey research design. The study population comprised married men currently residing in Ogbogu Community in&nbsp;&nbsp; Ogba/Egbema/Ndoni Local Government Area of Rivers State. A sample size of 389 persons was selected using a simple random technique. A structured questionnaire was used for data collection and data were analyzed using Statistical Package for Social Sciences (SPSS) windows (version 20.0). <strong>Results:</strong> The study showed that there is high awareness of family planning of among the married couples used for the study. Majority of the participants had detailed knowledge of condom. Also, the study indicated that married couples had a favourable attitude toward modern family planning methods of 51%, out of the married couples that were aware of modern family planning methods. Again, the study revealed that high percentage of married couples practice modern family planning methods. <strong>Conclusion:</strong> Knowledge of modern contraceptives is high in the study population. Substantial proportion of married couples had positive attitude towards modern contraceptives and hence more room for increasing modern contraceptive use in the study population.</p>

2024-02-29T00:00:00-07:00 Copyright (c) 2024 Udo Orukwowu https://scicomjournals.com/index.php/SJMAMS/article/view/15 2024-10-25T04:29:47-06:00 Olukayode Olusola Odubela odubela.olukayode@oouagoiwoye.edu.ng Emmanuel Sunday Omirin omirinemmanuelsunday@gmail.com Afeez John Olanrewaju olanrewajuj@babcock.edu.ng Ezekiel Abiola Olugbogi olugbogiezekiel@gmail.com Precious Oluwasanmi Aribisala preciousaribisala66@gmail.com Kingsley Chika Nwachukwu nwachukwuchikakingsley@gmail.com Ehisdiame Favour Okoh okohehisdiame@gmail.com Samson-Nse Blessed samsonnseblessed@gmail.com Samuel Oluwaseun Boboye sam.boboye@gmal.com

<p>The target of most cancer chemotherapeutic agents is to drive cancer cells toward death, necessitating the need to find a fine balance between anti-apoptotic and pro-apoptotic proteins in maintaining cellular homeostasis. Any shift favoring the pro-apoptotic proteins is needed to drive cellular death in cancer chemotherapy. Therefore, this study uses molecular docking, ADMET predictions, and molecular dynamics simulations for the identification of potent inhibitors of anti-apoptotic Bcl-2 from <em>Morus alba </em>(mulberry)<em>. </em>Our molecular docking study discovered that quercetin-3-(6- malonylglucoside) (-10.912kcal/mol) and epigallocatechin gallate (-9.750kcal/mol) recorded excellent binding affinity against human Bcl-2, better than popular standard drugs, venetoclax (-9.468(kcal/mol) and navitoclax (-9.058kcal/mol). Interactions profile summary clearly showed that hydrophobic interactions at TRP141, VAL145, and TYR105 were consistently maintained by the ligands, and all the compounds, except venetoclax, consistently maintained the hydrogen bonding at TYR105. MD simulation analysis showed that the protein and ligand RMSD for the quercetin-3-(6-malonylglucoside)-Bcl-2 complex fell within permissible range, suggesting the ligand is capable of functioning as apposite antagonists of Bcl-2. Epigallocatechin gallate also bind excellently with the target, and both ligands showed favorable ADMET parameters. Summarily, this study identifies two compounds of mulberry as potential drug candidate in the management of known human malignancies, and therefore suggest the compounds should further be assessed through <em>in vitro</em> and <em>in vivo</em> approaches to validate the reports documented here.</p>

2024-10-25T00:00:00-06:00 Copyright (c) 2024 Olukayode Olusola Odubela, Emmanuel Sunday Omirin, Afeez John Olanrewaju, Ezekiel Abiola Olugbogi, Precious Oluwasanmi Aribisala, Kingsley Chika Nwachukwu, Ehisdiame Favour Okoh, Samson-Nse Blessed, Samuel Oluwaseun Boboye